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> Re: Expedited appeal of denial of coverage for <> (DOB: xxx, SSN: ###, Tel: xxx) UHC #: xxx Group#: xxx Company: xxx File ID: xxx <> To Whom It May Concern: I am writing this letter on behalf of my patient, xxx (DOB: xxx, ID: xxx, Group# xxx), to request coverage for imatinib (Gleevec ) for the treatment of sclerotic chronic graft versus host disease. <> is a x y/o woman..describe case. Two separate European studies have suggested that imatinib is able to reverse the fibrosis associated with sclerotic chronic GVHD that has been refractory to multiple agents. A prospective study by the Italians (GITMO) in 19 patients with refractory chronic GVHD showed an overall response rate to imatinib at 6 months of 79% (Olivieri et al. Blood, Vol 114, No. 3, 709-718). A retrospective study by the French in 14 similar patients treated with imatinib showed an overall response rate of 50% (Magro et. al., Blood, Vol 114, No. 3, 719-722). Our own experience based on a prospective study done with Stanford, as well as our experience in subsequent non-study patients is that at least half the patients with sclerotic chronic GVHD have a clinically meaningful response. I appreciate your time and consideration of this matter and do hope that you will allow <<>> to be treated with imatinib. Please expedite your evaluation so that the patient may begin therapy as soon as possible as her sclerosis appears to be progressing. If you would like to discuss this case directly, please call me at (xxx) xxx-xxxx. Sincerely, <> Attachments: Olivieri et al. Blood, Vol 114, No. 3, 709-718 Magro et. al., Blood, Vol 114, No. 3, 719-722  >IQT[^ehjqruv~Խ{d{dMM-hzh?CJOJ^JaJfHq -hzh 8vCJOJ^JaJfHq 'hTKCJOJ^JaJfHq -hzh)CJOJ^JaJfHq -hzhk_CJOJ^JaJfHq -hzh{)CJOJ^JaJfHq -hzh uCJOJ^JaJfHq 'h6sCJOJ^JaJfHq  Jjv +, /p@ P !$`'gdl] /p@ P !$`'gd) gd)gd)      $ + c m Սvivivi\vOv\vvhzhl]OJQJ^Jhzh 8vOJQJ^JhzhOJQJ^Jhzh{)OJQJ^JhTKOJQJ^J,hzh{)OJQJ]^JfHq h6sOJQJ^J#hTKOJQJ^JfHq )hzhk_OJQJ^JfHq )hzh{)OJQJ^JfHq )hzhOJQJ^JfHq  . E = L Y Z e g o  9  % 2 P ` p (8:OP淢{{{qdZhTKOJQJ^Jhzh#wOJQJ^Jh:OJQJ^J)hzhdOJQJ^JfHq #h6sOJQJ^JfHq )hzhl]OJQJ^JfHq )hzh{)OJQJ^JfHq hzh 8OJQJ^JhzhOJQJ^Jhzh{)OJQJ^JhzhV45OJQJ^J",789:PQ_` /p@ P !$`'gd) gd) P hzh6OJQJ^JmHsHhzh6OJQJ^J8P:p{)/ =!"#F$% Dps2 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@_HmH nH sH tH @`@ NormalCJ_HaJmH sH tH DA D Default Paragraph FontViV  Table Normal :V 44 la (k (No List ZoZ G[Normal] 7$8$H$$CJOJQJ^J_HaJmH sH tH e@  GHTML Preformatted7 2( Px 4 #\'*.25@9B*CJOJPJ^JaJphPP  Balloon TextCJOJQJaJmHsHtHJ/!J Balloon Text CharCJOJQJaJB' 1B V45Comment ReferenceCJaJ<B< V45 Comment TextCJaJ@jAB@ V45Comment Subject5\PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭VvnB`2ǃ,!"E3p#9GQd; H xuv 0F[,F᚜K sO'3w #vfSVbsؠyX p5veuw 1z@ l,i!b I jZ2|9L$Z15xl.(zm${d:\@'23œln$^-@^i?D&|#td!6lġB"&63yy@t!HjpU*yeXry3~{s:FXI O5Y[Y!}S˪.7bd|n]671. tn/w/+[t6}PsںsL. J;̊iN $AI)t2 Lmx:(}\-i*xQCJuWl'QyI@ھ m2DBAR4 w¢naQ`ԲɁ W=0#xBdT/.3-F>bYL%׭˓KK 6HhfPQ=h)GBms]_Ԡ'CZѨys v@c])h7Jهic?FS.NP$ e&\Ӏ+I "'%QÕ@c![paAV.9Hd<ӮHVX*%A{Yr Aբ pxSL9":3U5U NC(p%u@;[d`4)]t#9M4W=P5*f̰lk<_X-C wT%Ժ}B% Y,] A̠&oʰŨ; \lc`|,bUvPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!R%theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK]  P , 8@0(  B S  ?9ACJ "%FN$(`hx{ 33qr~12(:Oqr~12(:Ouk_g)V45 8?hAl]6s 8vz\6: u{)h&s#wdTK$@@UnknownG*Ax Times New Roman5Symbol3. *Cx ArialI. ??Arial Unicode MScLucida GrandeTimes New RomanA$BCambria Math"1h&'(+  !F42QHP ? G2!xx Attn: __________________jmayorRebecca DepreyOh+'0  < H T `lt|Attn: __________________jmayor Normal.dotmRebecca Deprey5Microsoft Office Word@@.7d@~@By՜.+,0 hp   Seattle Cancer Care Alliance  Attn: __________________ Title  !"#$%&()*+,-.1Root Entry F`M{31TableWordDocument:SummaryInformation(DocumentSummaryInformation8'CompObjr  F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q