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History

Milestones in Hematopoietic Cell Transplantation

An article on hematopoietic cell transplantation by Karl G. Blume, MD, and these accompanying milestones were published in December 2008 as part of the special ASH anniversary brochure, 50 Years in Hematology: Research That Revolutionized Patient Care.

1868 The bone marrow is first described as blood-forming tissue.
1939 The first clinical marrow transplant is attempted, but unsuccessful.
1949-
1956
The humoral and cellular hypotheses of marrow reconstitution are debated.
1956-
1959
Efforts are renewed in marrow grafting in human diseases.
1956-
Present
Advances in marrow grafting through animal studies in murine and canine models.
1968-
1969
The first successful allogeneic HCT procedures are performed in patients with severe combined immunodeficiency diseases.
1975 The first large series of allogeneic HCT for leukemia is performed.
1977,
1980
Successful HCT procedures from unrelated marrow donors.
1978 The first series of successful autologous HCT for lymphoma is performed.
1987,
1989
Isolation of the murine and human hematopoietic stem cells is achieved.
1990 The Nobel Prize in Medicine/Physiology is awarded to E. Donnall Thomas for the development of HCT as a curative therapy for life-threatening hematologic disorders.
2008 More than 800,000 patients have been transplanted worldwide during the past four decades.
Citations